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This gradual escalation prevents overwhelming side effects like flushing, nausea, or headaches that occur when starting at high doses, allows the pituitary to adapt to regular stimulation improving long-term response, and provides opportunity to identify minimal effective dose avoiding unnecessary higher dosing and associated costs

This came from rodent studies where semaglutide (and similar drugs) caused thyroid tumors in rats

This information has not been evaluated by the FDA

These doses exceed what a single 1 mL syringe can hold, which means you either need to split the dose across two injections or move to a 20 mg/mL concentration

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